3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms

Oral dosage forms are by far the most common prescription and over-the-counter pharmaceutical used worldwide. However, many patients suffer from adverse effects caused their use of “one-size fits all” mass produced commercially available solid forms, whereby they do not receive dedicated medication or adjusted to specific needs. The development 3D printing paves way for personalised medicine. This work focuses on therapies hypertensive using nifedipine as model drug. printed full channelled spherical mini-tablets with enhanced surface area (1.6-fold higher) were modified PVA commercial filaments loaded passive diffusion (PD), Kollidon VA64 (KVA) ethylcellulose (EC) based prepared hot-melt extrusion (HME). Drug loading ranged 3.7% 60% employed technique, a 13-fold higher drug achieved HME compared PD. Composition was found have more significant impact dissolution than geometry area. Both KVA EC-based formulations exhibited biphasic zero-order drug-release profile. Physicochemical characterization revealed that in amorphous form KVA-based end-products which led greater control over 24 h period low levels crystallinity PXRD. proposed provide versatile technology high control, easily adaptable patient disease